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REDEFINE Trial Headlines Trial REDEFINE 1 Phase 3 Duration 68 weeks Population (N) 3,417 adults with obesity or overweight + 1 comorbidity, without T2D Key Result 20.4% mean weight change vs 3.0% placebo (treatment-policy)

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[419] While we continue to believe that standardized patient-reported outcome measures, utilized across different payors including Federal agencies, are important to enable comparison, [420] we also recognize that survey fatigue manifests in declining quality and quantity of survey responses and has become a significant issue in information collection

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