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We acknowledge the contributions of Dr

Heather Koehn, a pediatric otolaryngologist at Wellstar Childrens and assistant professor of pediatric otolaryngology at Augusta Universitys Medical College of Georgia

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While the structural basis of GLP-1R biased agonism between arrestin recruitment and G protein pathways is still not clear and will require additional studies to decipher, there is growing evidence that biased agonism is associated with the conformation and dynamics of the TM6/ECL3/TM7/TM1 domain 3,14,16,27,29 , and this is consistent with the data presented herein