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EWAS were considered as inconsistent if they lacked a replication or validation cohort [24], while targeted studies were downgraded for this category if their results were in contradiction with the literature

Difficulty adapting to change: Unexpected transitions, schedule changes, or new environments may cause distress or anxiety

Data were acquired in centroid mode across an m/z range of 501000, with a scan time of 0.4 s and interscan delay of 0.1 s