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In pancreatic -cells, PC2 cleaves proglucagon to yield mature glucagon (29 aa), glicentin-related pancreatic polypeptide (GRPP) and the major proglucagon fragment (MPGF)

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IV glutathione bypasses this degradation but has a half-life of only 1030 minutes, limiting sustained effect

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For individuals prescribed glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide (Ozempic, Wegovy, Rybelsus) or dulaglutide (Trulicity), understanding magnesium's role in metabolic health is relevant