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Discussion The crystallized inactive GLP-1R structure is not compatible with the known binding mode of GLP-1 requiring a conformational change of the ECD and a rearrangement of the TMD to enable binding of GLP-1

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The authors sincerely thank Rajvee Ortho Spine & Child Neuro Hospital, Ahmedabad, Gujarat, and Kalrav National Society for Equal Opportunities for the Handicapped (NSEOH), Ahmedabad, Gujarat, for their support in participant recruitment and clinical coordination