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In animal models, semaglutide reduces food intake and body weight by activating Adcyap1-expressing neurons in the dorsal vagal complex, a key integrator of gutbrain signals that induce a reduction in food intake via both homeostatic and hedonic pathways [78]

W.J.H., Elders, P.J.M., Lips, P., Dhonukshe-Rutten, R.A.M., Van Schoor, N.M., and De Groot, L.C.P.G.M

For weight loss, data from a 2021 review supports semaglutide as the most effective option

This may be further examined for the prognosis of disease progression

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Whats more, they replicated the same analyses in a separate cohort of patients with type 2 diabetes mellitus by comparing semaglutide with non-GLP1R agonist anti-diabetes medications