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TB4 (Thymosin Beta-4) is a naturally occurring peptide found throughout the body that regulates actin dynamics, recruits stem cells and progenitor cells to injury sites, reduces inflammation, and drives new blood vessel formation

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Phosphorylation of IGF-1R and subsequent activation of downstream signalling cascades were also found to contribute to tamoxifen resistance and drive cell proliferation in breast cancer (Kruger et al., 2020)