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| Side Effect | Semaglutide | Tirzepatide | Retatrutide | |-------------|-------------|-------------|-------------| | Nausea | Moderate (44%) | Moderate (42%) | Moderate-High (48%) | | Constipation | Common (24%) | Common (23%) | Common (26%) | | Diarrhea | Moderate (30%) | Moderate (27%) | Moderate (28%) | | Fatigue | Low (11%) | Low (10%) | Moderate (15%) | | Injection site | Low (3.2%) | Low (2.8%) | Low (3.5%) | Proper titration -- starting at the lowest dose and increasing gradually -- is the single most effective strategy for minimizing side effects across all medications

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