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3.9 Bile secretion and transportation were impaired in gallstone formation The proteins downregulated in CHL, in comparison to polyps, demonstrated enrichment in the KEGG pathway of bile secretion ( p adjusted = 0.039), which included ATP1B1, ABCC2, ABCB11, ABCB4, ABCB1, and ABCG8 (Figures 5D,E

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