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For this reason, we can hypothesize that the additional positive impact on glucose metabolism and body composition observed during the follow-up may be attributed to the addition of GLP-1RAs to the therapy

Farahani et al

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This once-weekly subcutaneous injection is not intended for long-term use at 0.25mg, but rather to help the body acclimate to semaglutide, minimizing gastrointestinal side effects before moving to higher therapeutic doses