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Subsequent introduction of two random mutations, Y444A and G484A, to D433N EcGGT variant further enhanced catalytic efficiency for GL-7-ACA substrate by 50-fold (Yamada et al., 2008)

What Does the Research Actually Say

Regulators are concerned that making the medicine widely available could lead to: Misdiagnosis: Patients self-treating a different, underlying condition

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Satheesh Babu AK, Petersen C, Iglesias-Carres L, et al

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