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As gastric emptying normalizes and appetite-suppressing signals fade, patients commonly experience reduced fullness and increased appetite as the medication's effects wane

Tirzepatide is not a hormone replacement therapy but influences metabolic hormones indirectly through its dual GIP/GLP-1 receptor actions, improving insulin secretion, reducing glucagon, and affecting appetite-regulating pathways

This practice requires careful monitoring and patient education about off-label use implications

Special Considerations Pregnancy Category C: Not recommended during pregnancy or breastfeeding