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Deficiency in vitamin B12 can lead to the accumulation of methylmalonyl-CoA, which is subsequently converted to methylmalonic acid (MMA) (70, 73)

Dig Dis Sci 38 : 665673

The initial effects of increased collagen and glycosaminoglycan synthesis become apparent

You can also supplement carnosine directly, but taking beta-alanine works better

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Several mechanisms underlying autoproteolysis were reported, but which is relevant for SnCE1 is unknown 75,103