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Sulfonylureas function by binding to and inhibiting the pancreatic ATP-dependent potassium channel that is normally involved in glucose-mediated insulin secretion (see Insulin Function, Insulin Resistance, and Food Intake Control of Secretion page for more details)

Reduced frequency maintains tissue support while minimizing ongoing costs and administration burden

NSF International (2023)

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FIN56, as a ferroptosis inducer, can inhibit the integration of Sec on the GPX4 catalytic subunit, thereby reducing the expression of GPX4s antioxidant activity (OU et al., 2022)

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