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At the 24-week mark, participants receiving the highest dose of retatrutide (12 mg) experienced a remarkable mean weight reduction of 17.5%, equivalent to an average weight loss of 41.2 pounds (18.7 kg)

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A key concept is that patients must strive for ketosis (not ketoacidosis) and monitor medical conditions closely

The theory is that overnight fasting reduces stomach acid production, creating a less hostile environment for probiotic organisms to survive the journey to the intestines