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The key concern is that people who start GLP-1 medications may differ in important ways from people starting other diabetes drugs. People who are starting GLP-1s could be more motivated to change their behaviors, be more engaged with their health care or receive more intensive follow-up from clinicians, Alexander said

Individual results vary based on starting metabolic status, genetic factors, and adherence to comprehensive lifestyle changes

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[15]Rashid A, Schutte BJ, et al

67 Interestingly, the functional interaction between DNA methylation and histone modification is crucial for sustaining heterochromatin homeostasis and stem cell genomic stability