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A meta-analysis of 35 studies of sleep disturbances with MPH in youth with ADHD found an impact of MPH on sleep-related adverse events, particularly for ER MPHs (Faraone et al., 2019), although individual clinical trials show conflicting results depending on specific characteristics of patients and the type of disturbance measured (Stein et al., 2012

References: Perricone, C., De Carolis, C., & Perricone, R

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Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

7.4.1 Targeted epigenetic interventions 7.4.1.1 Small-molecule epigenetic modulators Small-molecule epigenetic modulators, including DNA methyltransferase inhibitors and histone deacetylase inhibitors, may restore normal DNA methylation and histone acetylation patterns in individuals affected by EED exposure (145)

NNMT is an enzyme that converts nicotinamide to N-methylnicotinamide, consuming methyl groups and potentially reducing NAD+ availability