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Catalyzed by the condensation domain C* (CesA_C2), a second L- O -Val-L-Val-D- O -Leu-D-Ala- S -PCP, produced as described above, is then connected to the TE-bound tetradepsipeptide by esterification, thus forming the octadepsipeptidyl- O -TE intermediate ( DP8 ) and, further on, the dodecadepsipeptide- O -TE ( DP12 ) upon extension by a third L- O -Val-L-Val-D- O -Leu-D-Ala unit prior to macrolactonization to the cyclic twelve residue product cereulide (Fig

From metabolism to mind: the expanding role of the GLP-1 receptor in neurotherapeutics[J]

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Arbutin, particularly -arbutin, is widely used in cosmetic products for its significant skin-lightening effects 22 and relatively low cytotoxicity 28

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