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Experimentally resolved GLP-1R complexes with peptide agonists (e.g., GLP-1, exendin-4, and clinically used GLP-1 analogs) commonly exhibit contacts distributed across extracellular regions and the TM bundle similar to those found with neuromedin C, being characterized by cooperative interactions that stabilize active conformations required for G protein coupling (Kawai et al., 2020)

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Increment in carotid IMT of more than 0.34 mm/year can lead to a cardiovascular event with first myocardial infarction and stroke can happen with a carotid IMT above 0.882 mm and 0.75 mm, respectively 47

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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Giel K.E., Bulik C.M., Fernandez-Aranda F., Hay P., Keski-Rahkonen A., Schag K.Zipfel S