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Some patients try adjusting the dose

Rapid weight loss carries a small increased risk of gallstones

Slow it down too much and you get nausea, vomiting, constipation and/or diarrhea

53 Future Directions Migraine and mood disorders are highly comorbid conditions, both of which appear responsive to ketamine treatment, which raises the need for more research into the role of the glutamatergic pathway in migraine pathophysiology, as has been done for major depressive disorder and stress processing

For perspective on what these results look like in practice, real-world tirzepatide transformations confirm what the trials showed