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Among these, the valine-to-isoleucine substitution (V717I) was one of the first identified mutations, playing a pivotal role in the development of the amyloid cascade hypothesis of AD pathogenesis

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Inhibition activities were measured as described ( Activation and Inhibition of 12-LOX and 15-LOX in Cell-Free Assays The enzyme activities of 12-LOX and 15-LOX were assessed spectrophotometrically by measuring the formation of 12-HpETE and 15-HpETE, respectively

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