Although NDDs have been studied for many years, its pathogenesis is still not fully elucidated due to the complexity of pathogenic factors
doi: 10.1016/j.neurobiolaging.2005.03.016
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A method for preventing drug-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, a TRPV modulator, an MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of therapy with the drug, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration
All reactions were run in triplicate for at least three independent experiments
These findings suggest that the peptide affects not only tissue cells themselves but also the vascular environment, which is essential for regeneration
