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doi: 10.1371/journal.pone.0054442 160 KamezakiMKusabaTKomakiKFushimuraYWatanabeNIkedaKet al

In animal models of SARS, the passive administration of neutralizing antibodies to the virus resulted in attenuated disease 4 and, likewise, the induction of neutralizing antibodies via immunization in animal models of COVID-19 attenuated disease 2

however, the location of these mutations suggests there may be two interaction interfaces that are involved in regulating the KD (88)