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Finally, although genetic manipulation is one of the strengths of preclinical work, it is important to recognize that transgenic manipulations can induce developmental compensations in parallel pathways that can mask the overall effect of loss of the gene on surgical outcome

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Longevity and cellular health research explores fundamental processes that determine cellular and organismal lifespan

Li Q, Wu S, Li SY, Lopez FL, Du M, Kajstura J, Anversa P, Ren J: Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage