Treatment of type 2 diabetes with incretin-based therapies
Longer term: steady state and fuller effects With consistent weekly dosing, weight loss often continues gradually over many months before reaching a plateau
Systemic allergic symptoms require more urgent attention and include: Cutaneous manifestations : widespread urticaria (raised, itchy welts), generalised pruritus, flushing, or angioedema affecting the face, lips, tongue, or throat Respiratory symptoms : shortness of breath, wheezing, throat tightness, or stridor (high-pitched breathing sound) Gastrointestinal symptoms : nausea, vomiting, abdominal cramping, or diarrhoea (though these can also be common non-allergic side effects of GLP-1 agonists) Cardiovascular symptoms : dizziness, light-headedness, rapid or weak pulse, or feeling faint Anaphylaxis represents the most severe form of allergic reaction and is characterised by the rapid onset of symptoms affecting multiple organ systems
Lower concentration formulations require injecting more fluid
Injectable GLP-1s may be more suitable for: Patients aiming for the maximum possible reduction in body weight, those with co-existing conditions like heart disease or chronic kidney disease (due to specific FDA approvals for Ozempic), or those who prefer a simple weekly medication schedule
Comparing tirzepatide (Mounjaro) and semaglutide (Ozempic, Wegovy) Both drugs show promise not only in improving metabolic health, reducing hemaglobin A1C (hbA1C), and assisting with weight lossthe data also shows that they may reduce the likelihood of cardiovascular events such as heart attack or stroke and improve cardiovascular outcomes across the board