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To build on these findings, multi-omics approaches are essential to identify additional molecular targets and validate their function

This regulatory status may change

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The hypothalamus modulates pulsatile gonadotropin-releasing hormone (GnRH) secretion, which governs pituitary release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)

107109 It is therefore reasonable to hypothesize that weight reduction and improvements in metabolic parameters may lower cardiovascular risk in patients with IBD, representing a potential additional benefit of GLP-1RA therapy

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