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These complexes thus lead to a reduction in the hepatic secretion of insulin growth-factor-binding protein-I (IGFBP-I) and a consequent bioavailability of IGF-I, with the final effect of enhancing the androgen production by both interstitial and stromal cells of the theca (23) (Figure 1)

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Indeed, there was a positive correlation between glycemic level and WBC ROS accumulation only in LOsG-treated animals ( r = 0.61, n = 14, p 0.05)

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