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1 Total Randomized Trial Population Completer Population Upon discontinuation of treatment, patients are likely to regain weight 3-5 53% of Saxenda patients and 45% of patients on placebo completed the 3-year trial 3 The safety profile over 3 years was consistent with the profile at 1 year 3 Study 1 (3 years) 1,3 Results from a 160-week, randomized, double-blind, placebo-controlled study to evaluate the long-term safety and efficacy of Saxenda Adult patients with pre-diabetes and with a BMI of either 30, or 27 with at least 1 additional comorbidity were randomized to receive once-daily Saxenda (n=1,505) or placebo (n=749) in conjunction with a lifestyle modification program that included increased physical activity and a 500-kcal/day-deficit diet Patients underwent a 4-week dose-escalation period followed by 156 weeks on the full dose, with a 12-week off-drug observational follow-up period The study evaluated percentage of patients achieving weight loss of at least 5% of body weight at both 1 and 3 years Mean baseline body weight was 236.7 lb and mean BMI was 38.8 kg/m 2 In patients with obesity, losing weight causes changes in appetite hormones that can actually increase hunger and the desire to eat

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To make the results more comparable, only GLP-1 products that are weekly injection pens were included in the analyses

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Managing nausea from day one: timing, meals, and hydration Managing GI side effects during titration starts before the injection

Then, the sections were observed and photographed under a microscope