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2A and B), whereas it was effective in reducing HbA1c, total cholesterol and FBS (Fig

When pathogens are detected, through mechanisms like pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), or through detection of pathogen toxins, mucus-producing cells can dramatically increase mucin production and secretion (Rada et al., 2011

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Indeed, our results revealed that the dose-response curves for GluK3 N-glycan mutants are left shifted with respect to wild type receptor

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This successful HSCT demonstrated that reversal of SCD could be achieved without complete reversal of the hematological phenotype to HbAA, and paved the way for bone marrow transplant (BMT) as a curative option for children with severe SCD (Walters et al., 1996b)