[1] [3] Sequence and modified residues -Glu 1 Cys 2 Asn 3 Thr 4 Ala 5 Thr 6 Cys 7 Ala 8 Thr 9 Gly 10 Orn 11 Leu 12 Ala 13 Glu 14 (-methyl-Phe) 15 Leu 16 Val 17 Arg 18 Ser 19 Ser 20 Asn 21 (N2-methyl-Asn) 22 Phe 23 Gly 24 Pro 25 Lys 26 (C20 diacid-Glu 2 )Leu 27 Pro 28 Pro 29 Thr 30 Glu 31 Val 32 Gly 33 Ser 34 Asn 35 Thr 36 Tyr 37 NH 2 Here, -Glu denotes a -glutamyl residue and should not be interpreted as pyroglutamate (pGlu) unless specifically demonstrated by structural nomenclature
Statistics The experimental data were analyzed utilizing standard parametric statistics including Student's t -test, one-way ANOVA or log-rank test where applicable as indicated in the figure legends
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Instead, our findings demonstrate an important role for GSH in the liver, where under resting conditions, GSH maintains low NRF2 activity to permit ample expression of lipogenic enzymes, promotes the production of triglycerides, and sustains lipid abundance in vivo
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When reconstituted with bacteriostatic water and stored consistently in a refrigerator, our experience shows the AHK-Cu solution remains stable and potent for at least 4 to 6 weeks
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