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Br J Haematol, 2010

Aly AS, Cram AE, Heddens CJ

Modern research into bitter compounds, such as alkaloids, has shown that these phytochemicals in foods and herbs target bitter taste receptors, specifically TAS2Rs, found throughout the digestive system

Intestinal FXR mediates the hepatic T3 action on GLP-1 and glucose homeostasis To test whether intestinal FXR signaling was essential for the T3 action observed in this study, intestine-specific FXR-null mice (IFXRKO) were employed 31

Subsequently, 0.4 mL of a PI staining/lysis solution (0.5% NP-40, 0.5 mM ethylenediaminetetraacetic acid [EDTA]) and 50 L of RNase A (10 mg/mL in TrisEDTA buffer, pH 8.0) solution were added

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