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Cardiometabolic disease is used as an umbrella term for all the above cases, and severity of cardiometabolic disease refers, in this manuscript, to the progression from single risk factors such as obesity to overt T2D and cardiac phenotype (ischemic heart disease and heart failure)

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As a bioregulator, it is exclusively found in the Thymic gland and upregulates the synthesis of white blood cells (t cells)

Snyder et al., 2011