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Higher doses (10-25g) are used in modified protocols but require G6PD screening beforehand, as high-dose vitamin C can trigger haemolysis in deficient patients

Peptide researchers call this "thermal burden"

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It is contraindicated in certain conditions such as active malignancy and must be used cautiously in those with diabetes, prediabetes, or a history of pituitary disease, which is why careful screening and regular monitoring are essential