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The calculator labels 0.1 mg as a trace entry, 0.3 mg as the measured signal floor, 0.5 mg as the default microdose target, and 1 mg as the upper microdose target

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However, after a large dose of APAP, the sulfonation reaction becomes saturated and the build-up of NAPQI depletes GSH in the liver, causing further accumulation of NAPQI

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