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Immunity 46 , 562576 (2017)

Neve (2009) Functional Selectivity of G Protein-Coupled Receptors: New Opportunities for Drug Discovery

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If animals receive an adequate amount of vitamin E but are deficient in selenium signs include hair loss, slow growth, and reproductive failure

However, indirect mechanismsincluding reduced caloric intake from appetite suppression, gastrointestinal symptoms affecting nutrition, and metabolic changes from weight lossmay contribute to feelings of fatigue