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Sources Once-Weekly Semaglutide in Adults with Overweight or Obesity (2021) The New England Journal of Medicine [accessed 10th February 2026] Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial (2022) Nature Medicine ] [accessed 10th February 2026] Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity (STEP 4) (2021) JAMA ] [accessed 10th February 2026] Semaglutide 2.4 mg once weekly in adults with overweight or obesity, and type 2 diabetes (STEP 2 Trial) (2021) The Lancet ] [accessed 10th February 2026] Wegovy 0.25 mg, 0.5 mg, 1 mg, 1.7 mg and 2.4 mg solution for injection in pre-filled pen (2024) Electronic Medicines Compendium (EMC): Patient Information Leaflet ] [accessed 10th February 2026] Wegovy (semaglutide) Summary of Product Characteristics (2024) Electronic Medicines Compendium (EMC) ] [accessed 10th February 2026] MHRA approves GLP-1 receptor agonist semaglutide to reduce risk of serious heart problems in obese or overweight adults (2024) GOV.UK ] [accessed 10th February 2026] Semaglutide and Cardiovascular Outcomes in Patients With Overweight or Obesity (SELECT Trial) (2023) PubMed / SELECT CVOT Overview [accessed 10th February 2026] A Research Study to Look at How Well Semaglutide Helps People Lose Weight (STEP UP Phase 3b) (2024) ClinicalTrials.gov ] [accessed 10th February 2026] Wegovy (semaglutide) Injection: Your Complete Guide to Wegovy Pen (2026) Novo Nordisk ] [accessed 10th February 2026] Semaglutide for managing overweight and obesity (2023) NICE ] [accessed 10th February 2026] Medically reviewed by reviewed by Tannaz Sohrabi (MPharm, PGDip, IP, MRPharmS) GPhC Number: 2225756 Last reviewed: 17th April 2026 Meet our medical professionals medical professionals Sunny Dhain Clinical Director Kamaldeep Kaur Pharmacist Prescriber Aaliyah Nelson Nutritional Coaching BSc (Hons) Nutrition: 47988 Standards first always always

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(Patients learn to pinch the skin and insert the needle straight in, usually at a 90 angle.) Rotating sites is important for example, switching between different areas of the abdomen to avoid tissue changes