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Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

1.6 Biochemical and metabolic profiling The pathogenesis of neurodegenerative disorders generally involves a complex physiopathology that includes age-related changes, abnormal function and accumulation of brain proteins, inflammation, disruption of energy homeostasis, hormonal imbalances, metabolic imbalances, DNA damage, among other processes (Gadhave et al., 2024)

These symptoms are typically worst during the first few weeks and often improve with time

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