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Historically, we have stated that we consider all items related to the surgical outcome and provided during the hospital stay in which the surgery is performed, including postsurgical pain management drugs, to be part of the surgery for purposes of our drug and biological surgical supply packaging policy (79 FR 66875)

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This was corroborated by a marked effect on cAMP signaling in -arrestin-less HEK293 cells, which progressively diverged with longer exendin-4 treatment, reminiscent of the effect of exendin-phe1 on beta cell cAMP production

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