tirzepatide and cardiovascular outcomes In the SUMMIT trial, researchers examined of treatment with in patients with heart failure with preserved ejection fraction obesity. Full trial results and Plain Language Summary: https://nej.md/4hRGaTY Medthreads Effects of Tirzepatide on the

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However, clinical translation is currently constrained by small sample sizes, heterogeneity in dosing, short trial durations, and an overrepresentation of individuals with comorbid obesity, leaving gaps in evidence for normal-weight patients and those with psychiatric comorbidities

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Modern liver-specific IGF-1 knockout studies have shown that local IGF-1 contributes substantially to tissue IGF1R activation, separate from the endocrine pool