Notably, maintaining an optimal balance of antioxidants, including glutathione, may be key in managing inflammation and disease progression in patients with IBD
Based on these findings, it is likely that the glutathione metabolism markers had good sensitivity and specificity for the diagnosis of ASD, and future clinical studies should be well designed to validate this hypothesis
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Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]
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