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According to the structures solved here and the AlphaFold3 model, two sites, i.e., Lys209 and Lys248, were in the vicinity to the bound CoA, and acetylation might therefore sterically and electrostatically interfere with CoA binding (Figs

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We used Metascape to conduct a multiple database (including GO Biological Processes, KEGG Pathway, a Reactome gene set and WikiPathways) enrichment analysis, and construct a PPI network

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