Carnitine analogs produced by the gut microbiota can colocalize with carnitine in the white matter of the brain and inhibit carnitine-mediated FAO in cell culture models of mouse CNS white matter, affecting the hosts nervous system, which provides a new perspective for understanding the complexity of the gutbrain axis [252]
doi:10.1186/s12958-018-0346-x ScienceDirect
[6] ISMAIL, A.M
Journal de lAssociation Medicale Canadienne [Canadian Medical Association Journal] , 184 (18), 19751976
Gregory Lubiniecki, vice president of oncology clinical research at Merck Research Laboratories, noted in a statement that prognoses are generally poor for this disease and said the company is pleased to offer a new first-line treatment option. The approval was backed by results from the Phase II/III KEYNOTE-483 trial, where Keytruda elicited a significant survival benefit for patients, cutting the risk of death by 21%
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