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These enzymes also neutralize oxidizing molecules, so glutathione has a one-two punch of directly and catalytically counteracting oxidants

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Concerning mPGES-2s, they were initially not considered as GSTs because GSH was not absolutely required for the detected activity e.g., the isomerization of ProstaGlandin H 2 (PGH 2 ) (Tanikawa et al., 2002) and because they exhibited a low similarity with GSTs identified at that time

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10.1074/jbc.271.9.4653 J