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Similar content being viewed by others Introduction Hepatic steatosis, characterized by excessive accumulation of triglycerides (TGs) in hepatocytes, is considered the cause of nonalcoholic fatty liver disease (NAFLD) 1,2,3

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Enhanced Stability : Modifications to its structure improve its efficacy and half-life, allowing for once-weekly dosing ( 6 )

Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure

In support of this mechanism, the experimental drugs GTX-102 ( ION582 ( and RO7248824 ( utilize NAT-targeting ASOs and are currently undergoing phase 1/2 clinical trials in pediatric and adult AS patients