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Nanotechnology has even higher hurdles to overcome including complex syntheses with expensive reagents some of which will not be GRAS, as well as lack of quantitative evidence of particle uptake in vivo , but at least the GI physiology aspects are now better understood along with improved in vivo imaging

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Diabetes Care 2011;34:818-22.PubMedPMC 60

doi:10.1002/humu.23658.

The collagen is extracted by boiling skin, bones, scales, or cartilage, and then hydrolyzedbroken down enzymaticallyto create smaller peptides that are more easily absorbed by the body (Liu, 2015)