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Within hours of treatment, research models begin showing increased NAD+ levels and reduced 1-MNA production, but the full spectrum of metabolic changes develops over days to weeks as downstream signaling cascades adjust to the new metabolic environment

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Strikingly, our data identified MITF as a novel ECM- and mechanosensitive transcription factor, with a stiffness-dependent increase as well as the highest nuclear localization observed on COL I compared to COL IV and FN