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This triple mechanism distinguishes retatrutide from existing approved weight loss peptides such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 receptor agonist), although direct head-to-head trials comparing these agents have not been conducted, and comparative efficacy has not been established

Int J Pharm (2021) 597:120347

Protein shakes designed for GLP-1 users offer a convenient way to hit protein targets, especially during periods of reduced appetite

Given the network effects of obesity and the added mortality impact of social isolation/loneliness among individuals with obesity, new interventions should be studied to promote social connectivity in conjunction with GLP-1 use [191,192]

Both GIP receptor agonism and antagonism were able to reduce body weight or prevent diet-induced obesity in mice [18]