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The elevated DNA damage and altered DNA methylation are risks for cancer and play essential roles in neurological, and developmental abnormalities and cognitive defects (66)

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Forest plot analysis revealed significant improvements in menstrual frequency across all active interventions compared to placebo: GLP-1 RAs demonstrated a WMD of 3.58 (95% CI 3.54, 4.16), metformin showed a WMD of 3.76 (95% CI 3.42, 4.1), GLP-1 RAs/metformin combination achieved a WMD of 3.95 (95% CI 3.48, 4.42), and roflumilast exhibited a WMD of 3.99 (95% CI 3.63, 4.35) (Fig

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Diet: Include fresh fruits and vegetables, proteins and whole grain into the diet to get full nutrients