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It activates pathways such as ERK1/2 and FAK-paxillin, which are involved in cell growth and migration

For example, under sustained heat stress, HSP70 levels increase more significantly than those of other heat shock proteins (Tandara et al., 2006

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But other researchers have found Nox4 is considered to be the main active subtype of chondrocytes in OA cartilage, in which the activation of Nox4 by proinflammatory cytokines increases the production of O 2 and H 2 O 2 (Morel et al., 2015)