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Consequently, elevated levels of TMAO accumulate in organs such as the kidneys and heart, triggering processes including foam cell formation, platelet aggregation, and inflammatory responses

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Despite limited clinical evidence exists regarding the comprehensive cardiovascular impacts of concurrent treatment with these agents in patients with T2D 18,19,20 , and preclinical studies suggest potential synergistic effects for MASLD 17 , there is a critical need for robust clinical research to evaluate the effect of combined SGLT2is and GLP-1RAs in patients with MASLD

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